B12 and folic acid relationship counseling

Specifically, B12 and folic acid (or folate) are making headlines for their roles in and B-vitamins is homocysteine levels, but the relationship is intriguing. mentioned above, it is worth consulting with your physician and/or a. When it comes to folate and vitamin B, maintaining the proper ratio of these You're probably more familiar with its synthetic form, folic acid, which is used to. The vitamins folic acid and B serve as coenzymes in one-carbon metabolism. its specific link to vitamin B deficiency, but not folate deficiency, may provide .. The effects of combined folic acid and liver extract therapy.

However, experimental investigation of this hypothesis is unethical, and the few existing observational data are inconclusive. This may be used for the synthesis of thymidylate, a DNA nucleotide, or for purine synthesis. Folate deficiency-related macrocytic anemia is due to failure of precursor blood cells to divide because of a lack of DNA.

The MOST Common Cause of a B12 Deficiency

Vitamin B acts as a cofactor for methionine synthase MSwhich catalyzes the remethylation of homocysteine to methionine. Hyperhomocysteinemia is another consequence of deficiencies of either folate or vitamin B 2.

This effect is due, in part, to the requirement by MS for both folate and vitamin B S-adenosylmethionine also serves as the sole methyl donor for the central nervous system, which may explain associations between folate deficiency and vitamin B deficiency and cognitive impairment and mental illness 34. One of the most devastating consequences of vitamin B deficiency is a classic neuropathy called combined degeneration of the spinal cord 5.

The mechanism by which vitamin B deficiency leads to this fatal demyelinating illness is unknown, but its specific link to vitamin B deficiency, but not folate deficiency, may provide a clue to the causal pathway. Another unique consequence of vitamin B deficiency relates to its role in the isomerization of L-methylmalonyl—coenzyme A CoA to succinyl-CoA—a reaction that, unlike the remethylation of homocysteine, occurs in the mitochondria and does not involve folate.

Thus, vitamin B deficiency specifically results in increased methylmalonic acid MMA concentrations in both plasma and urine. Pernicious anemia and excessive intake of folic acid After studying malnourished pregnant women in India in the late s, Lucy Wills described a macrocytic anemia that shared some features with the blood abnormalities of elderly Europeans with pernicious anemia 6.

For example, the cytologic properties of the 2 anemias were identical, and both types responded well to crude liver extract.

However, only the tropical illness responded to yeast extract. Furthermore, although purified liver extract had proved effective in the treatment of pernicious anemia, it did not cure the tropical form 6.

This hypothesis was subsequently verified.

Vitamin B12 And Folic Acid | Dr. Schweikart

However, the identification of vitamin B as the anti—pernicious anemia factor in liver 7 followed the isolation of folic acid from yeast 8 by several years, during which time folic acid was administered in large doses to patients with pernicious anemia 9.

Because the inappropriateness of this treatment quickly became apparent, reports of cases thus treated in the late s and early s comprise the entire body of literature on the effect of folic acid administration on persons deficient for vitamin B 10 — Reviews of the historic case reports allude to rapid neurologic deterioration after improvement of anemia 10 High blood levels of homocysteine have been linked with the risk of arterial disease, dementia and Alzheimer's disease.

There is therefore interest in whether dietary supplements of folic acid an artificial chemical analogue of naturally occurring folates can improve cognitive function of people at risk of cognitive decline associated with ageing or dementia, whether by affecting homocysteine metabolism or through other mechanisms.

There is a risk that if folic acid is given to people who have undiagnosed deficiency of vitamin B12 it may lead to neurological damage.

Folic acid with or without vitamin B12 for cognition and dementia.

Vitamin B12 deficiency produces both an anaemia identical to that of folate deficiency but also causes irreversible damage to the central and peripheral nervous systems.

Folic acid will correct the anaemia of vitamin B12 deficiency and so delay diagnosis but will not prevent progression to neurological damage. For this reason trials of folic acid supplements may involve simultaneous administration of vitamin B Apparent benefit from folic acid given in the combination would therefore need to be "corrected" for any effect of vitamin B12 alone.

A separate Cochrane review of vitamin B12 and cognitive function is being prepared. To examine the effects of folic acid supplementation, with or without vitamin B12, on elderly healthy and demented people, in preventing cognitive impairment or retarding its progress. All double-blind placebo-controlled randomized trials, in which supplements of folic acid with or without vitamin B12 were compared with placebo for elderly healthy people or people with any type of dementia or cognitive impairment.

The reviewers independently applied the selection criteria and assessed study quality. One reviewer extracted and analysed the data.

In comparing intervention with placebo, weighted mean differences, and standardized mean difference or odds ratios were estimated.

Folic acid with or without vitamin B12 for cognition and dementia.

Four randomized controlled trials fulfilled the inclusion criteria for this review. One trial Bryan enrolled healthy women, and three Fioravanti ; Sommer ; VITAL recruited people with mild to moderate cognitive impairment or dementia with or without diagnosed folate deficiency.

One trial VITAL studied the effects of a combination of vitamin B12 and folic acid on patients with mild to moderate cognitive impairment due to Alzheimer's disease or mixed dementia.